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APR-246 Chemical Structure

APR-246

Cat. No. :BCP20294CAS No. :5291-32-7Purity:98%
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Synonyms APR 246;APR246;Prima-1met
CAS Number 5291-32-7
Purity 98%
M. Wt 199
Formula C10H17NO3
Storage Store at 4-8°C
APR-246 is a quinuclidinone derivative that targets the Wrap53 gene with potential antineoplastic activity. p53 activator APR-246 binds to and activates transcription of the Wrap53 gene, which results in an increase in WRAP53 p53 antisense transcript levels and, potentially, an increase in native p53 activity; in turn, increased p53 activity may lead to an induction of cell cycle arrest and apoptosis in tumor cells. This agent may work synergistically with other antineoplastic agents.

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