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Histone Methyltransferase

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Histone Methyltransferase

Chemical Structure Cat. No. Product Name CAS No.
BIX 01294 trihydrochloride hydrate Chemical Structure
BCP38667 BIX 01294 trihydrochloride hydrate 1808255-64-2
BIX 01294 trihydrochloride hydrate, a diazepin-quinazolinamine derivative, is a histone-lysine methyltransferase (HMTase) inhibitor that modulates the epigenetic status of chromatin.
GSK3368715 dihydrochloride Chemical Structure
BCP38359 GSK3368715 dihydrochloride 1628925-77-8
GSK3368715 dihydrochloride is a novel potent type-I protein arginine methyltransferases (PRMTs) inhibitor.
LEM-14 Chemical Structure
BCP38013 LEM-14 1814881-70-3
LEM-14 is a specific NSD2 inhibitor.
TM2-115 Chemical Structure
BCP38007 TM2-115 1197196-47-6
TM2-115 is a potent histone methyltransferase inhibitor with rapid antimalarial activity against all blood stage forms in Plasmodium falciparum
A-196 Chemical Structure
BCP37560 A-196 1982372-88-2
A 196 is a potent and selective inhibitor of SUV420H1/H2 (IC50 = 25 and 144 nM, respectively) with 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. It was shown to inhibit the di- and tri-methylation of H4K20me in multiple cell lines (IC50 < 1 μM).
Ezh2-IN-2 Chemical Structure
BCP37576 Ezh2-IN-2 2238821-31-1
EZH2-?IN-?2 is a EZH2 inhibitor.
BAY-598 Chemical Structure
BCP37130 BAY-598 1906919-67-2
BAY-598 is selective small molecule inhibitor of SMYD2 with an IC50 of 27 nM.
CPI-1612 Chemical Structure
BCP36917 CPI-1612 2374971-81-8
CPI-1612 is an orally bioavailable EP300/CBP histone acetyltransferase inhibitor
CPI 169 R-enantiomer Chemical Structure
BCP36903 CPI 169 R-enantiomer 1802175-07-0
CPI 169 R-enantiomer is a novel and potent EZH2 inhibitor.
MS1943 Chemical Structure
BCP36892 MS1943 2225938-17-8
MS1943 is a first-in-class, orally bioavailable EZH2 selective degrader. It significantly reduces EZH2 protein levels in numerous triple-negative breast cancer (TNBC) and other cancer and noncancerous cell lines. MS1943 effectively blocks proliferation of multiple TNBC and other cancer cell lines.
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