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PROTAC

Chemical Structure Cat. No. Product Name CAS No.
ERD-308 Chemical Structure
BCP38904 ERD-308 2320561-35-9
ERD-308 is a highly potent PROTAC degrader of estrogen receptor (ER) for ER positive breast cancer treatment. ERD-308 induces >95% of ER degradation at concentrations as low as 5 nM in both cell lines (DC50 (concentration causing 50% of protein degradation) of 0.17 nM and 0.43 nM in MCF-7 and T47D ER+ cells, respectively).
Pyrene-PEG2-azide Chemical Structure
BCP38903 Pyrene-PEG2-azide 2135330-58-2
Pyrene-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
(S,R,S)-AHPC-CO-PEG2-C2-amine HCl Chemical Structure
BCP38881 (S,R,S)-AHPC-CO-PEG2-C2-amine HCl 2138439-54-8
SJFα Chemical Structure
BCP38794 SJFα 2254609-27-1
SJFα is a 13-atom linker PROTAC.
PROTAC FLT-3 degrader 1 Chemical Structure
BCP38793 PROTAC FLT-3 degrader 1 2230826-81-8
PROTAC FLT-3 degrader 1 is an FLT-3 internal tandem duplication (ITD) degrader with an IC50 0.6 nM.
PROTAC IRAK4 degrader-1 Chemical Structure
BCP38792 PROTAC IRAK4 degrader-1 2360533-90-8
PROTAC IRAK4 degrader-1 is a degrader of PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4).
PROTAC MDM2 Degrader-4 Chemical Structure
BCP38791 PROTAC MDM2 Degrader-4 2249750-24-9
PROTAC MDM2 Degrader-4 is a MDM2 degrader based on PROTAC technology.
Thalidomide-NH-PEG2-C2-NH2 Chemical Structure
BCP38790 Thalidomide-NH-PEG2-C2-NH2 2093416-32-9
Thalidomide-O-amido-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.
Thalidomide-NH-C6-NH2 TFA Chemical Structure
BCP38789 Thalidomide-NH-C6-NH2 TFA 2093386-51-5
Thalidomide-NH-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
(S,R,S)-AHPC-amido-C5-acid Chemical Structure
BCP38788 (S,R,S)-AHPC-amido-C5-acid 2162120-87-6
(S,R,S)-AHPC-amido-C5-acid incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used to design XY028-133.
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