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RIP

Chemical Structure Cat. No. Product Name CAS No.
GSK-963 Chemical Structure
BCP37994 GSK-963 2049868-46-2
GSK-963 is a potent and selective inhibitor of RIP1 kinase.
GSK962 Chemical Structure
BCP37995 GSK962 2049872-86-6
GSK962 is a negative control for GSK'963, a highly potent and selective RIP1 inhibitor.
GSK-843 Chemical Structure
BCP37845 GSK-843 1601496-05-2
GSK-843 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM.
RIPK1-IN-4 Chemical Structure
BCP35149 RIPK1-IN-4 1481641-08-0
RIPK1-IN-4 is a potent and selective type II kinase inhibitor of receptor interacting protein 1 (RIP1) kinase and binds to a DLG-out inactive form of RIP1 with an IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase.
Necrostatin 2 racemate Chemical Structure
BCP26072 Necrostatin 2 racemate 852391-15-2
Necrostatin 2 racemate (Nec-1S), the Nec-1 stable, is a potent and specific RIPK1 inhibitor lacking the IDO-targeting effect.
GSK2983559 Chemical Structure
BCP23871 GSK2983559 1579965-12-0
GSK2983559 is a potent, specific and oral bioavailable receptor interacting protein 2 (RIP2) kinase inhibitor.
PK68 Chemical Structure
BCP32187 PK68 2173556-69-7
PK68 is a potent and selective type II inhibitor of receptor-interacting kinase 1 (RIPK1) with an IC50 of ~90?nM, displays inhibition of RIPK1-dependent necroptosis.
GSK3145095 Chemical Structure
BCP31015 GSK3145095 1622849-43-7
GSK3145095 is a RIP1 kinase inhibitor with an IC50 of 6.3 nM .
GSK547 Chemical Structure
BCP30590 GSK547 2226735-55-1
GSK547 is a highly selective and potent inhibitor of RIP1 kinase that targets RIP1 in vivo.
HS1371 Chemical Structure
BCP30268 HS1371 2158197-70-5
HS-1371 is a potent and ATP-competitive RIP3 inhibitor with an IC50 of 20.8?nM.
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