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Wnt

Chemical Structure Cat. No. Product Name CAS No.
Pyrvinium pamoate Chemical Structure
BCP38435 Pyrvinium pamoate 3546-41-6
Pyrvinium pamoate is a naphthoic acid. It has a role as an anticoronaviral agent.
G244-LM Chemical Structure
BCP37837 G244-LM 1563007-08-8
G244-LM is a potent and specific small-molecule tankyrase inhibitors, which reduces Wnt/β-catenin signaling by preventing poly(ADP-ribosyl)ation-dependent AXIN degradation, thereby promoting β-catenin destabilization.
Adavivint Chemical Structure
BCP36799 Adavivint 1467013-03-3
Adavivint is a Wnt pathway inhibitor.
MSAB Chemical Structure
BCP35746 MSAB 173436-66-3
MSAB is a selective inhibitor of Wnt/β-catenin signaling.
PRI-724 Chemical Structure
BCP32677 PRI-724 1422253-38-0
PRI-724 is a selective inhibitor of the CBP/β-catenin interaction.
KY1220 Chemical Structure
BCP34008 KY1220 292168-79-7
KY1220 is a small molecule that simultaneously degrades β-catenin and Ras by inhibition of the Wnt/β-catenin pathway.
CHIR-99021 trihydrochloride Chemical Structure
BCP26069 CHIR-99021 trihydrochloride 1782235-14-6
CHIR99021 is an orally active and potent GSK3 inhibitor. CHIR-73911 exhibited GSK3 IC50 in the low nanomolar range and excellent selectivity. CHIR-73911 activates glycogen synthase in insulin receptorexpressing CHO-IR cells and primary rat hepatocyte
iCRT3 Chemical Structure
BCP32691 iCRT3 901751-47-1
iCRT3 is an inhibitor of both Wnt and β-catenin-responsive transcription.
QS11 Chemical Structure
BCP02472 QS11 944328-88-5
Additionally, Wnt Synergist, QS11 has been shown to work synergistically with Wnt-3a to specifically activate the Wnt/β-catenin signaling pathway in vitro. A Super(8X)TOPFlash reporter assay using HEK293 cells revealed increases in basal transcription activity by application of QS11 (2-fold), Wnt-3a (40-fold), and QS11/Wnt-3a (200-fold).
Adavivint Chemical Structure
BCP30409 Adavivint 1467093-03-3
Adavivint is a potent and selective inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCF/LEF-reporter assay in SW480 colon cancer cells.
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